https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27866 Wed 24 Nov 2021 15:53:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30070 Wed 24 Nov 2021 15:53:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30922 Wed 24 Nov 2021 15:50:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33368 Wed 23 Feb 2022 16:02:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36978 Wed 19 Jul 2023 11:51:12 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31015 Wed 17 Nov 2021 16:28:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25616 Wed 17 Nov 2021 16:28:15 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25483 Wed 15 Dec 2021 16:10:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13782 Wed 11 Apr 2018 16:59:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15067 Wed 11 Apr 2018 16:52:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15057 Wed 11 Apr 2018 16:51:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9766 Wed 11 Apr 2018 15:10:05 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22624 Wed 11 Apr 2018 14:54:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30635 Wed 11 Apr 2018 14:17:01 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:16035 Wed 11 Apr 2018 13:36:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15358 Wed 11 Apr 2018 13:14:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20530 Wed 11 Apr 2018 13:07:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22609 Wed 11 Apr 2018 13:07:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27665 Wed 11 Apr 2018 12:19:59 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22867 Wed 11 Apr 2018 12:18:18 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12420 Wed 11 Apr 2018 11:53:47 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22323 Wed 11 Apr 2018 11:25:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15484 Wed 11 Apr 2018 11:00:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14130 Wed 11 Apr 2018 10:59:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22793 Wed 11 Apr 2018 10:52:40 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7473 21) with self-reported diabetes were recruited by convenience sampling at a public event organized by Diabetic Society of Singapore to commemorate the World Diabetes Day. Correlation between diabetes knowledge (measured using the General Diabetes Knowledge Test (GDKT), score range 0-100) and HRQoL (measured using the Audit of Diabetes-dependent Quality of life (ADDQoL), score range 0~100;EQ-5D, score range-0.594 to 1) were studied using Pearson correlation coefficients. The relationship between diabetes knowledge and HRQoL was studied using 3 separate multiple linear regression (MLR) models with HRQoL scores as dependent variable and GDKT score as independent variable. No adjustment was made in the first MLR model,while socioeconomic variable(s) and socioeconomic and medical status variables were adjusted respectively in the other 2 models. Results: Data from 42 subjects with complete responses were analyzed (mean (SD) age:53.0(9.61) years, 45% female, 90% with >6 years of education, 64.3% with other chronic medical conditions, 40.5% with diabetes complications). Mean (SD) GDKT, ADDQoL and EQ-5D scores were 33.1(3.53), 46.9(18.56) and 0.9(0.15) respectively. Correlations between diabetes knowledge and ADDQoL and EQ-5D scores were 0.26 and 0.30 respectively. A comparatively modest predictive power of diabetes knowledge was found to explain the variances in ADDQoL and EQ-5D of around 12% (Model II). Conclusion: Our results showed diabetes knowledge to be modestly correlated with both diabetes-specific and generic HRQoL, indicating that diabetes knowledge may be useful as a predictor of HRQoL when modeled properly. Yet, further studies utilizing larger sample size would be required to confirm the observation.]]> Wed 11 Apr 2018 10:51:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15730 Wed 11 Apr 2018 10:28:14 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14444 Wed 11 Apr 2018 10:07:56 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31102 Wed 11 Apr 2018 10:05:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36659 Wed 10 Nov 2021 15:14:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35136 Wed 10 Nov 2021 15:04:22 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30849 Wed 09 Feb 2022 15:52:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32810 Wed 06 Apr 2022 14:04:33 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34482 Wed 06 Apr 2022 13:56:45 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32209 Wed 04 Sep 2019 12:18:34 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35005 Thu 30 May 2019 12:17:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30825 Thu 28 Oct 2021 13:03:53 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25916 in utero may also predispose to later-life disease development. The Gomeroi gaaynggal study was established to explore intrauterine origins of renal disease, diabetes and growth in order to inform the development of health programmes for Indigenous Australian women and children. Pregnant women are recruited from antenatal clinics in Tamworth, Newcastle and Walgett, New South Wales, Australia, by Indigenous research assistants. Measures are collected at three time points in pregnancy and from women and their children at up to eight time points in the child's first 5 years. Measures of fetal renal development and function include ultrasound and biochemical biomarkers. Dietary intake, infant feeding and anthropometric measurements are collected. Standardized procedures and validated tools are used where available. Since 2010 the study has recruited over 230 women, and retained 66 postpartum. Recruitment is ongoing, and Gomeroi gaaynggal is currently the largest Indigenous pregnancy-through-early-childhood cohort internationally. Baseline median gestational age was 39.1 weeks (31.5-43.2, n=110), median birth weight was 3180 g (910-5430 g, n=110). Over one third (39.3%) of infants were admitted to special care or neonatal nursery. Nearly half of mothers (47.5%) reported tobacco smoking during pregnancy. Results of the study will contribute to knowledge about origins of chronic disease in Indigenous Australians and nutrition and growth of women and their offspring during pregnancy and postpartum. Study strengths include employment and capacity-building of Indigenous staff and the complementary ArtsHealth programme.]]> Thu 28 Oct 2021 12:36:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33671 Thu 27 Jan 2022 15:56:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24305 Thu 17 Mar 2022 14:38:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25914 Thu 17 Mar 2022 14:37:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25504 Thu 17 Mar 2022 14:36:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27617 Thu 17 Feb 2022 09:29:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30851 Thu 17 Feb 2022 09:28:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33539 Thu 15 Nov 2018 15:26:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30991 Thu 04 Nov 2021 10:40:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28299 Thu 04 Nov 2021 10:39:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9274 Sat 24 Mar 2018 11:12:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9379 Sat 24 Mar 2018 10:45:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9369 Sat 24 Mar 2018 10:45:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9376 Sat 24 Mar 2018 10:45:35 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11980 Sat 24 Mar 2018 10:32:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8237 Sat 24 Mar 2018 08:40:42 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7470 Sat 24 Mar 2018 08:38:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9556 Sat 24 Mar 2018 08:34:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:1189 Sat 24 Mar 2018 08:28:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14339 Sat 24 Mar 2018 08:21:25 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10640 Sat 24 Mar 2018 08:13:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:11059 Sat 24 Mar 2018 08:10:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12193 Sat 24 Mar 2018 08:08:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20448 Sat 24 Mar 2018 08:06:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18231 Sat 24 Mar 2018 08:04:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18828 Sat 24 Mar 2018 08:03:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19441 Sat 24 Mar 2018 08:02:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17396 Sat 24 Mar 2018 08:01:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21153 Sat 24 Mar 2018 08:00:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21866 Sat 24 Mar 2018 07:59:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17877 Sat 24 Mar 2018 07:56:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19725 P<0.05), miR-103 (P<0.01), and miR-107 (P<0.05) expression, a decrease in IR (P<0.05), phopsho- Akt (P<0.01), and phospho-FoxO1 (P<0.01) abundance, and a paradoxical decrease in 11ßHSD1 (P<0.05), PEPCK-C (P<0.01), and PEPCK-M (P<0.05) expression in lambs. These changes were ablated by a period of moderate dietary restriction imposed during the periconceptional period. Maternal dietary restriction alone also resulted in decreased abundance of a separate subset of hepatic insulin-signaling molecules, namely, IRS1 (P<0.05), PDK1 (P<0.01), phospho-PDK1 (P<0.05), and aPKCζ (P<0.05) and in decreased PEPCK-C (P<0.01) and G6Pase (P<0.01) expression in the lamb. Our findings highlight the sensitivity of the epigenome to maternal nutrition around conception and the need for dietary interventions that maximize metabolic benefits and minimize metabolic costs for the next generation.-Nicholas, L. M., Rattanatray, L., MacLaughlin, S. M., Ozanne, S. E., Kleemann, D. O.,Walker, S. K., Morrison, J. L., Zhang, S., Muhlhausler, B. S., Martin-Gronert, M. S., McMillen, I. C. Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring.]]> Sat 24 Mar 2018 07:53:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:19718 n = 287) were randomly assigned to a control group or an intervention group (i.e., print-based materials/pedometer group or print-based materials/pedometer plus telephone-counseling group). Changes in PA and A1c and other clinical measures were examined by Linear Mixed Model analyses over 18 months, along with moderating effects for gender and age. Results: PA and A1c levels did not significantly change in intervention groups. Step counts significantly increased in the print-based materials and pedometer plus telephone counseling group, for women. Conclusions: No significant effects were found for PA or A1c levels for T2DM adults. The multi-component strategy including telephone counseling may have potential for women.]]> Sat 24 Mar 2018 07:53:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21041 Sat 24 Mar 2018 07:50:36 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:5358 Sat 24 Mar 2018 07:43:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27120 Sat 24 Mar 2018 07:41:34 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27825 Sat 24 Mar 2018 07:41:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29106 Sat 24 Mar 2018 07:39:56 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25372 Sat 24 Mar 2018 07:39:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28654 Sat 24 Mar 2018 07:37:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29378 Sat 24 Mar 2018 07:36:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28500 Sat 24 Mar 2018 07:29:16 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28535 Sat 24 Mar 2018 07:28:48 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25680 Sat 24 Mar 2018 07:28:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4888 Sat 24 Mar 2018 07:21:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22186 Sat 24 Mar 2018 07:16:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22658 Sat 24 Mar 2018 07:15:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22538 Sat 24 Mar 2018 07:14:47 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23421 Sat 24 Mar 2018 07:13:54 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23691 Sat 24 Mar 2018 07:13:26 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23795 Sat 24 Mar 2018 07:13:18 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22305 Sat 24 Mar 2018 07:11:06 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:25014 Sat 24 Mar 2018 07:10:50 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32330 Mon 23 Sep 2019 12:41:35 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32392 Mon 23 Sep 2019 10:46:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32072 Mon 23 Sep 2019 10:24:40 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35057 Mon 17 Jun 2019 10:29:54 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44085 Mon 10 Oct 2022 08:58:49 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32078 Fri 27 Apr 2018 12:41:50 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35105 Fri 21 Jun 2019 09:57:56 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:18433 Fri 12 May 2017 15:42:27 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31991 1 year (RAAS2). An augmented inverse-probability weighting (AIPW) method was used to estimate potential-outcome mean (POM) and average treatment-effect (ATE). Multi-logit and Poisson regressions were used for treatment and outcome models, respectively. Analyses were stratified by ESRD, death before/after ESRD for diabetic and non-diabetic groups. STATA 14.0 was used for statistical analyses. Results: Among 15,032 diabetic patients, 2346 (15.6%), 2351 (18.5%), and 1607 (68.5%) developed ESRD, died before ESRD, and died after ESRD, respectively. Only RAAS2 effect was significant on ESRD, death before and after ESRD. The ESRD rates were 12.9%, versus 20.0% for RAAS2 and non-RAAS, respectively, resulted in significant risk differences (RD) of -7.2% (95% CI: -8.8%, -5.5%), and a numbers needed-to-treat (NNT) of 14. Death rates before ESRD for these corresponding groups were 14.4% (12.9%, 15.9%) and 19.6% (18.7%, 20.4%) with a NNT of 19. Death rates after ESRD in RAAS2 was lower than non-RASS group (i.e., 62.8% (55.5%, 68.9%) versus 68.1% (65.9%, 70.4%)) but this was not significant. RAAS2 effects on ESRD and death before ESRD were persistently significant in non-diabetic patients (n = 17,074) but not for death after ESRD with the NNT of about 15 and 16 respectively. Conclusions: Receiving RAAS blockade for 1 year or longer could prevent both CKD progression to ESRD and premature mortality.]]> Fri 01 Apr 2022 09:26:45 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:32794 cystC and mean creatinine clearance in the offspring. Additional experimental and longitudinal prospective studies are warranted to confirm this relationship, especially in Indigenous populations where the risk of renal disease is greater.]]> Fri 01 Apr 2022 09:23:14 AEDT ]]>